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History PT-141 was developed in the 1990s through structural modification of Melanotan II, aimed at generating a melanocortin analog with reduced activity at pigmentation-related MC1R while retaining MC3R/MC4R agonist activity

Zhang S., Ikramuddin S., Beckwith H

However, in vivo and ex vivo research suggest that maternal diabetes may potentially dysregulate fetal glucocorticoid sensitivity

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