In fact, around 25% of people with an autoimmune condition tend to develop three or more autoimmune conditions, likely due to a combination of genetic and environmental factors
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Binding induces autophosphorylation of the intracellular kinase domain on tyrosines 1131/1135/1136, recruits substrates IRS-1, IRS-2 and Shc, and activates two major signaling pathways: the PI3K-AKT-mTOR pathway (protein anabolism, cell growth, apoptosis inhibition) and the Ras-Raf-MEK-ERK pathway (cell proliferation, growth gene transcription)
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Sarkaria JN, Hu LS, Parney IF, Pafundi DH, Brinkmann DH, Laack NN, Giannini C, Burns TC, Kizilbash SH, Laramy JK, Swanson KR, Kaufmann TJ, Brown PD, Agar NYR, Galanis E, Buckner JC, Elmquist WF