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[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Zhu X, Fowler MJ, Wells QS, Stafford JM, Gannon M

This structure has been shown to improve peptide chemical stability and to extend in vivo activity 15,16 and could provide some stability benefit when in antibody fusion

However, most current studies rely solely on the EAE mouse model and the LPC-induced localized myelin loss model, which do not fully recapitulate the complex pathological features of MS, particularly its heterogeneity, disease progression, and clinical symptoms

Missing a single week typically causes a weight loss plateau rather than significant regain