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However, individuals with pre-existing heart conditions should consult their doctor before starting treatment

As has been previously proposed, the ability to specifically block negative regulators of muscle mass could provide profound therapeutic benefit in multiple settings 10 ranging from individuals (such as the elderly) suffering from muscle atrophy and weakness, to the obesity setting where increases in muscle can drive energy expenditure that can help with weight control but also provide metabolic benefit

Cross-referencing with the UniProtKB database (50) and existing literature revealed a total of 11 proteins associated with histone or chromatin regulatory functions, visualized as a heat map (51) in Fig