The SURMOUNT-1 trial (N=2,539) reported a vomiting rate of 12.2% for tirzepatide 15 mg, lower than the 24.8% seen with semaglutide 2.4 mg in STEP 1, although cross-trial comparisons have significant limitations [16]
For example, if you: Find it difficult to complete work and home responsibilities due to low mood
Which compound should be the starting point for GLP-1 research
Approximately 10-20% of people dont achieve significant weight loss on semaglutide due to genetic factors, medication interactions, or hormonal differences
Doctors are saying, Okay, well, take your GLP-1s and this is going to make you less motivated for food, but we somehow expect you to have more motivation to change your diet and to exercise. If its gonna dampen your desire to kind of eat, isnt it also going to dampen your desire, like that high you get from working out, or that [thought], Hey, I wanna be healthier, maybe I should go for a salad. If you think the only reason to eat better is to lose weight and something else is making you lose weight, that might actually give you inherently less motivation to eat better.
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