As levels drop, oxidative damage accumulates, the livers detoxification capacity diminishes, and cellular health declines, contributing to fatigue, inflammation, skin changes, and increased disease risk over time
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While injectable GLP-1 medications themselves are unlikely to have clinically significant interactions with laxatives, they may delay absorption of other oral medications due to slowed gastric emptying
NHS access began in specialist weight management services from June 2025 for the highest-need patients, with tirzepatide prescribing incorporated into the GP Quality and Outcomes Framework from April 2026