In November this year, Eli Lilly submitted an application for the marketing of tirpotide to global regulators for the treatment of patients with heart failure with preserved ejection fraction (HFpEF) and obesity
She thought the side effects werent worth the little weight she had lost, so she decided to go off the drug
For weight management, approved GLP-1 medications like semaglutide (Wegovy) and tirzepatide (Zepbound) are the evidence-based options
GLP-1RAs inhibit chondrocyte apoptosis, reduce inflammation, and protect articular chondrocytes in OA and RA through various mechanisms, including suppressing cytokine release, inhibiting the NF-B pathway, and reducing inflammation-related gene expression
This episode delivers actionable protocols you can implement immediately while understanding the "why" behind every compound choice