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The team discusses recent trends in citrulline dosing, with Mike mentioning "citrulline arms races" with doses reaching 12 grams in some products

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This inhibition preserves cellular NAD+ levels by reducing their consumption, simultaneously increasing GLUT4 transporter expression and activating sirtuin 1, known as the "longevity gene." The compound exhibits high membrane permeability and selectivity without affecting related methyltransferases or NAD+ salvage pathway enzymes, creating targeted metabolic effects while maintaining cellular safety

This combination approach has gained recognition for dramatically accelerating recovery from both acute injuries and chronic pain conditions