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Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside

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Key Results After matching: Overweight cohort (n=710) Risk ratio: 0.748 Absolute risk reduction: 14.6% Obese cohort (n=1,515) Risk ratio: 0.790 Absolute risk reduction: 12.2% Morbidly obese cohort (n=1,249) Risk ratio: 0.780 Absolute risk reduction: 13.3% Across all BMI categories, GLP-1 initiation was associated with a meaningful reduction in asthma exacerbation risk

Not a hard ceiling, but a validated benchmark across multiple molecules and sponsors

But it does not match the numbers that retatrutide puts up as a monotherapy