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During treatment, it may be necessary to seek medical advice if side effects worsen or persist for longer than a few weeks or months, or if serious adverse effects occur

Avoid alcohol while taking either medication

[1] [2] Thyroid monitoring : If you have hypothyroidism, your GP or endocrinologist should continue regular thyroid function monitoring (typically TSH and free T4) as per standard care, usually annually once stable or more frequently during dose adjustments

Regular resistance training preserves lean mass and supports insulin sensitivity through mechanical pathways that complement GLP-1 activation

Patients should be counseled on: Dietary sodium restriction to 1,5002,300 mg daily for those with hypertension Regular physical activity with at least 150 minutes of moderate-intensity aerobic exercise weekly, plus resistance training 23 days per week Reducing prolonged sitting by breaking up sedentary time throughout the day Adequate hydration , particularly important given semaglutide's gastrointestinal effects Alcohol moderation to no more than one drink daily for women and two for men Stress management techniques including mindfulness and adequate sleep Patients should be educated about proper home blood pressure monitoring techniques if self-monitoring is recommended