Poor lifestyle choices and environmental factors (e.g., pollution) accelerate this decline
In cases in which GSSG is not able to be reduced quickly enough, GSSG can be exported via protein sulfhydryl groups
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Furthermore, it was demonstrated that pharmacological stabilization of cardiolipin, a key lipid in the mitochondrial membrane, can reverse the energy dysfunction observed in vitiligo melanocytes, which suggests that manipulating cardiolipin could be a promising new therapeutic strategy for treating vitiligo.43 Vitiligo skin shows morphological changes in the epithelium and in the upper dermis
In each of these instances, the anti-tumor effect of AG-120 was comparable or superior (i.e., tumor shrinkage) to a previous study of anti-IDH1-mutant tumor therapy ( 43 )