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As an example, Liu and co-workers designed a Fe 2+ -contained and PEG-modified nanocatalyst reacting with overexpressed H 2 O 2 to generate sufficient OH, which is able to kill tumor cells ( 2 nanoparticles encapsulated with Cu-ferrocene for oxidating GSH, named CCF ( 2+ , which released from decomposed CCF in an acidic environment, triggered GSH exhaustion (Figure 5A) and Cu + -mediated Fenton-like reaction, avoiding the potential OH elimination

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However, the physiological importance of DHARs in ascorbate regeneration has been recently called into question

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Kurtz A, Grant K, Marano R, Arrieta A, Grant K Jr, Feaster W, et al