however, their effects are often modest and short-lived, with hypotension limiting sustained clinical use.32 Anti-inflammatory and NF-B targeted therapies can attenuate cytokine-mediated injury.33,34,40 Calcium channel blockers reduce intracellular calcium overload and cellular injury but demonstrate variable clinical efficacy and limited impact on inflammatory and oxidative pathways.41 Similarly, statins, dexmedetomidine, and antioxidant therapiesincluding N-acetylcysteine, allopurinol, and hydrogen-rich saline target reactive oxygen species and have shown protective effects in preclinical models
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Adequate hydration helps manage nearly every side effect associated with Pendulum
Designing prodrug molecules using senescence-associated -galactosidase (SA--gal) has become a potential strategy to improve target specificity and reduce platelet toxicity
