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For those worried about the cost, programs like TrimRX could be worth exploring

First, we emulated the two cardiovascular outcome trials SUSTAIN-6 (semaglutide versus placebo) and SURPASS-CVOT (tirzepatide versus dulaglutide) using the RCT-DUPLICATE approach to benchmark findings and inform the study design and analytic approach for expanded questions

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These medications can be highly effective for weight loss and blood sugar management, but because they slow digestion and gastric emptying, some patients may experience fewer bowel movements, harder stools, or discomfort

While these mechanisms contribute to its therapeutic benefits, they also explain why gastrointestinal side effects are among the most commonly reported adverse reactions