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Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem

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The published surveillance data has not identified an increased melanoma rate in the small EPP-treated population

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The fluorescence signal of ROS was measured using a flow cytometer, employing the FITC channel