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Other aspects of the physiology of thymic epithelial cells can also be modulated by hormones and neuropeptides, particularly cytokeratin expression, cell growth and production of extracellular matrix proteins, thus characterizing the pleiotrophic action of these molecules on the thymic epithelium

In a large year-long clinical trial, briakinumab was effective in the treatment of moderate-to-severe psoriasis

2020;33(4):e13531

and one published human clinical study examining intra-articular injection in 12 patients with chronic knee pain, of whom 7 out of 12 reported relief lasting over 6 months [15]

But even that is rare