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According to predictions from the KEGG database, metformin has been shown to significantly increase the activity of glutamate-cysteine ligases in microbial metabolism

10.1016/s1474-4422(02)00164-3 36 JacobS.W.De la TorreJ

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Starting with lower doses helps minimize any adjustment effects

The common allele is cytoprotective against the toxic effects of chemotherapeutics, whereas the functionally less competent allele is thought to increase the toxicity of anticancerogenic drugs in patients with this gene variant due to decreased metabolic activity of impaired enzyme