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When the reverse pattern is present (normal free T 3 level and elevated free T 4 level), the differential includes thyroiditis, exogenous levothyroxine ingestion, and hyperthyroidism in the elderly, often with suppressed T 4 to T 3 conversion due to comorbid illness (Table 128-2)

15 Phase II trials targeting MASH have shown that treatment with SEMA 0.4 mg daily for 72 weeks resulted in more patients with liver fibrosis stage F2/F3 achieving improvement in MASH without progression of liver fibrosis (odds ratio = 6.87, 95% CI = 2.6017.63) compared to placebo

It is an oligopoly, a market structure dominated by a small number of large, powerful firms