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Copper can aggravate neurotoxicity by accelerating the formation of advanced glycation endproducts (AGEs), while AGEs upregulate the expression of RAGE (receptor for AGEs) and the activation of glycogen synthase kinase3 [184]

However, because we have determined that the cost of reporting on this measure outweighs the benefits of retaining it in the program, we are removing these measures at the earliest feasible reporting period of CY 2025, for which the submission period has not yet opened and the deadline would not be until in May 2026

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Dosage and Frequency Once a week Taken on the same day each week, any time of day, with or without food

In a 48-week phase 2 trial in people with T2D and obesity, 10 mg/kg bimagrumab was associated with a marked reduction of fat mass (20.5% vs