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Maximum: 20 mg daily Extended release Initial: 2.55 mg once daily with first main meal Maximum: 20 mg daily Glimepiride (Amaryl) Dosage Initial: 12 mg once daily with first main meal Maximum: 8 mg daily Possible side effects include: Hypoglycemia Weight gain Meglitinides (glinides) Primary mechanism(s) of action Meglitinides stimulate insulin release by pancreatic beta cells

Intermittent dosing allows MC1R receptors to re-sensitise between administrations, preserving melanogenic response over extended timeframes

Concurrently, Ipamorelin acts as a selective agonist for the growth hormone secretagogue receptor type 1a (GHS-R1a), also known as the ghrelin receptor

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doi: 10.1089/ars.2013.5346 69 NakanoMImamuraHSasaokaNYamamotoMUemuraNShudoTet al