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In this Perspective, we summarize data on cancer incidence from trials and registries in individuals with type 2 diabetes, describe the actions of GLP-1 medicines on preclinical cancer models and highlight possible direct and indirect mechanisms linking GLP-1R signaling to cancer development and progression

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There is, however, a short-term spike in thyroid cancer diagnoses within the first year of initiation, likely due to increased surveillance (i.e., more thyroid ultrasounds and monitoring), not a direct causal effect