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Growth hormone release is closely coupled to slow-wave sleep, and the broader GHRH literature demonstrates that GHRH signaling can influence sleep-endocrine activity, particularly non-REM and slow-wave sleep parameters in controlled experimental settings [5]

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Neurobiological outcomes included changes in dopaminergic signaling, neuroinflammatory markers, circulating insulin and GLP-1 levels, and activation of reward-related brain regions