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Table 1 Key trials for ARNIs SGLT2 INHIBITORS IN CMS SGLT2 inhibitors have become a cornerstone therapy for CMS due to their multifaceted benefits.44 Initially developed to improve glycemic control in type 2 diabetes mellitus, these agents have demonstrated profound cardiovascular and renal protective effects, regardless of baseline glycemic status.45 SGLT2 inhibitors reduce renal glucose reabsorption, which resulted in glucosuria and caloric loss46 and contributes to weight reduction and improved insulin sensitivity, both key factors in CMS management

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