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Wegovy and Zepbound: What Makes Them Different

Semaglutide is administered once a week via a subcutaneous injection

It may be that short-acting GLP-1RAs act more like endogenous GLP-1 and communicate to the brain primarily via the vagus nerve, whereas long-acting GLP-1RAs like liraglutide and semaglutide primarily access the brain directly

In STEP 1, the largest trial (N = 1961), 38 participants were randomized to receive onceweekly subcutaneous semaglutide 2.4 mg or matching placebo for 68 weeks

Furthermore, absorption is specific to the compounds used: for example, liraglutide is not absorbed when co-formulated with SNAC, likely because it is too hydrophobic