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Some retrospective data shows patients on antidepressants lose slightly less weight overall on GLP-1 agonists, but this likely reflects the underlying depression rather than a pharmacological conflict

Clinical Evidence for Non-Obese Weight Loss Outcomes Tirzepatide, a dual GIP/GLP-1 receptor agonist, has shown particular effectiveness in producing weight loss across BMI categories

As a methodological proof-of-concept only, we additionally performed a Bayesian network meta-analysis restricted to body-weight change within a prespecified 1216-weeks window in the largest connected treatment network

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That we know can meaningfully reduce mechanical stress, systemic inflammation and metabolic burden