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The combination of the N-terminal amine, the histidine imidazole, and the intervening amide nitrogen is a recurrent high-affinity copper-binding motif in peptide biochemistry it appears in human serum albumin's N-terminal copper-binding site, in various other copper-binding peptides, and in synthetic copper-binding peptide design

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One group received local injection directly into the bone defect

AOD-9604's value is more mechanistic (isolated lipolysis study) than outcome-driven