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doi: 10.1161/STROKEAHA.116.012934 Chen Y, Zhang X, He J, Xie Y, Yang Y

Females taking spironolactone may experience menstrual irregularity, including postmenopausal bleeding, breast tenderness or mastalgia, hirsutism, deepened voice, and amenorrhea

Physiologically, GDF15 is expressed in many tissues at a low concentration, but increases in expression with tissue damage, cancer, metabolic diseases, CVD and inflammation

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