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When two agonists bind the same receptor, the second one isn't adding a new signal it is competing for finite binding sites on a pathway that is already being stimulated

As individuals age, the bidirectional communication between muscle and vascular systems becomes compromised, resulting in a reduction of capillary density, a decrease in the bioavailability of endothelial nitric oxide (NO), and an overall decline in muscle perfusionthese elements collectively contribute to the intensification of anabolic resistance and the acceleration of sarcopenic progression (5, 6)

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