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Subclinical hypothyroidism (elevated TSH with normal free T4) is also not a contraindication, though optimisation of thyroid function before initiating weight management therapy is often advisable

Second, glycine prevents aggregation by interacting with exposed hydrophobic regions on the peptide surface

The emerging thinking among those working in this field, and reflected in a statement by the Endocrine Society, is that obesity is due to two related but distinct processes: the already mentioned energy imbalance (eating more calories than the body expends) and the resetting of the body weight set point the weight that the body determines as its goal to a higher value

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Weight stability is a win