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The majority of the subjects (83.6%) showed improvement in global wrinkle scores, skin elasticity (via cutometer) and skin texture, tone, and radiance after 3 months of treatment

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Overall, metformins properties extend beyond glycemic control, encompassing antioxidative and cellular protective effects that contribute to its therapeutic benefits (Figure 2) (Samsuri et al., 2017

Also, IL-18 can damage intestinal barrier, as it has been involved in tight junction modulation, mucosal apoptosis [123] and in inhibiting goblet cell maturation [124]