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A transient cytokine mixture of epidermal growth factor and ciliary neurotrophic factor activates Stat3 signaling, leads to in vivo conversion of acinar-to- cells, and reverses alloxan-induced diabetes in mice[98]

Less common adverse effects have included pruritic rash, muscle weakness in uremic patients, and seizures in patients with seizure disorders

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Its only controlled human trial a Phase II study for postoperative ileus failed its primary endpoint , and clinical development was discontinued [5]

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