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Therefore, our finding that SFN has an immunosuppressive effect on untransformed human T-cells may explain why treatment with SFN did not lead to amelioration of cancer severity in patients as demonstrated in a number of clinical trials ( in vitro experiments on tumor cells such as breast cancer cell and hepatocellular carcinoma cell strongly suggested that SFN has anti-tumor properties (63)

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Notably, the groups with more substantial relevance to our topic were typically supported by a larger body of literature (63 articles), while those with weaker biological associations were supported by fewer publications (5 articles)

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The labeled ladder is 2.5, 5, 7.5, 10, 12.5, and 15 mg once weekly, with each escalation step held for at least four weeks