The following table synthesizes key clinical findings to support informed treatment conversations: Metabolic Biomarkers That Inform Treatment Selection Before starting either medication, assessing fasting glucose, HbA1c, insulin levels, and HOMA-IR (insulin resistance index) can clarify whether metformin's insulin-sensitizing action or GLP-1's appetite-suppression pathway aligns better with your metabolic phenotype
References References Selective and membranepermeable small molecule inhibitors of NNMT Roles of Nicotinamide NMethyltransferase in Obesity and Type 2 Diabetes Nicotinamide Nmethyltransferase inhibition mimics and boosts exercisemediated improvements in muscle function in aged mice Reduced calorie diet combined with NNMT inhibition establishes a healthier gut microbiome in obese mice Kraus et al
Your body has been sending you signals
The decrease in Lactobacillus may lead to a pro-inflammatory environment, increasing the expression of HPV E6 and E7 genes and malignant cell proliferation (Nieves-Ramrez et al., 2021)
Each cage was identified with dates, number of studies, group, dose, number, and sex of each animal
