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Serine phosphorylation of IRS-1 (at residues s312/s616/s636) deactivates and decouples insulin signalling, and thus elevated expression of IRS-1 s312 is recognised as a proxy marker of NInsR 1113

GLP-1 receptor agonists work in part by slowing gastric emptying, which is what prolongs fullness and reduces appetite

Paul Peppard, a sleep medicine researcher at the University of Wisconsin who was not involved in the study, said losing weight has long been recommended as a way to reduce the severity of sleep apnea by expanding lung capacity, reducing fat in the airways and improving oxygen usage

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