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The most commonly reported first-day effects include mild nausea (reported by roughly 12 to 18 percent at the 2.5 mg starting dose), decreased appetite without feeling sick, slight fatigue or drowsiness, and a vague sense of stomach fullness

[PUBMED Abstract] Mathiak M, Rtten A, Mangold E, et al.: Loss of DNA mismatch repair proteins in skin tumors from patients with Muir-Torre syndrome and MSH2 or MLH1 germline mutations: establishment of immunohistochemical analysis as a screening test

Taking too many supplements or too much of one vitamin can lead to imbalances or even toxicity