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The angiogenesis and disruption of liver vascular architecture have been linked to progression to cirrhosis and liver cancer in chronic liver diseases, which contributes to both increased hepatic vascular resistance and portal hypertension and decreased hepatocyte perfusion [119,120,121]

They are also necessary for the interconversion of amino acids such as the metabolism of histidine to glutamic acid and the interconversion of serine and glycine

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