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Additionally, Mn activates numerous enzyme systems, some of which are responsible for safeguarding plants from specific environmental stressors, such as drought, winter cold, salt damage, and ozone damage as well as specific soil-borne diseases and fungal leaf diseases (Alejandro et al., 2020)

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The highly reactive oxygen intermediates can cause serious chemical damage to DNA, proteins, and unsaturated lipids and can lead to cell death

In male albino rats exposed to Titanium dioxide nanoparticles (TiO 2 NPs), the leaf extract reduced levels of KIM-1, thereby preventing interstitial renal inflammation and fibrosis (Abdou et al