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This interaction is competed by the cellular FLICE-inhibitory protein (c-FLIP): ROS have been shown to downregulate the c-FLIP half-life by inducing its ubiquitin-proteasomal degradation, thus enhancing this extrinsic pathway 76

19 and 20show the quantified percent protection (normalized to nave) graphs for outer hair cells (OHCs) and spiral ganglion neurons (SGNs).FIG

(See Chapter 9) Autoimmune disease is usually takes an ongoing process and Hashimoto's thyroiditis develops into hypothyroidism

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Recent studies have emphasized the antioxidant and anti-inflammatory properties of N-acetylcysteine (NAC), demonstrating its potential to reduce oxidative stress and inflammation in various organs