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Rotate the site every time, because injecting the same spot repeatedly can cause a fatty lump (lipohypertrophy) that slows absorption, a point the NHS is clear about when it advises you to rotate sites daily

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The initial step in this process is recognition by intracellular pattern recognition receptor (PRR) nucleotide-binding oligomerisation domain protein 1 (Nod 1) (36)

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doi: 10.1016/j.joca.2014.09.024 91