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Nei dati di ricerca disponibili non sono state osservate prove di un significativo aumento del cortisolo, di alterazioni della prolattina o di effetti avversi epatici

Disulfiram acts by inducing nausea upon alcohol consumption, naltrexone is a mu-opioid receptor antagonist, therefore having broad action on the reward system, and the action of acamprosate is less well understood, but it is likely an allosteric modulator of GABAa receptors

Pouwer F, Snoek FJ, van der Ploeg HM, Adr HJ, Heine RJ (2001) Monitoring of psychological well-being in outpatients with diabetes: effects on mood, HbA 1c , and the patients evaluation of the quality of diabetes care: a randomized controlled trial

Participants were excluded if they used these drugs in the year before enrolment or had contraindications to them