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The research rationale established by NNMT-knockdown studies in diet-induced-obese mice is that inhibiting NNMT preserves intracellular NAD+ and SAM levels, which in adipocyte (fat-cell) models has been shown to suppress de novo lipogenesis

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It is recommended to frequently monitor blood levels of potassium and platelet counts in these individuals for early detection and appropriate management of any abnormalities

It is important to highlight that CSF2 and CXCL10 encode pro-inflammatory proteins linked to neurodegenerative diseases 51,52,53 , and, as mentioned above, elevated levels of CXCL10 protein are associated with persistent VCD in individuals from the same cohort of the present study 20