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While we didnt see phase 3 insulin sensitivity data, its clear that it profoundly reduces that just based on phase 2 data
Antiretroviral Toxic Neuropathy Antiretroviral toxic neuropathy is the commonest human immunodeficiency virus (HIV)-associated distal symmetrical polyneuropathy caused by nucleoside analogue reverse transcriptase inhibitors used for the treatment of HIV [78]
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This was thought to be due to increased levels of 2,3-DPG in red blood cells , which off-loads more oxygen at the working muscle