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These effects can be troublesome and may require dose adjustments or treatment discontinuation

But theres a catch

These mechanisms are driving each other in a continuous feedback loopand addressing any one of them in isolation, while ignoring the others, produces limited results

If two experiences activate partially overlapping circuits, this leads to the tagging of synapses close in space (e.g., clustered on the same dendrites) and the co-activation of some neurons shared by these experiences (Figure 1A)