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Because EtO is a cancer-causing chemical with serious effects accumulating over time (often many years), even relatively modest exposures matter if they repeat over months and years, especially for people who are chronically exposed (via home/work/school near the facility)

One potential explanation for the significantly increased chimerism of the secondary transplants of the young Mda5 -/- is the increase in the frequency of the LSKs and HSCs in the primary transplant (not significant due to the transplanted animals with very low chimerism)

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[49] Zinman B, Gerich J, Buse JB, et al