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Novel combination therapy with hepsin and low doses of NAC improves therapeutic effectiveness and extends survival in APAP-induced lethality The standard clinical approach for treating APAP-induced liver injury involves administering NAC

doi: 10.1016/j.tplants.2018.10.010 102 JouMJPengTIHsuLFJouSBReiterRJYangCMet al

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This multi-stage process may eventually lead to the disturbance in the structure of membrane of the vacuole (tonoplast) leading to the leakage of lytic enzymes into the intracellular environment of yeasts causing acidification [2, 38]