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2) This study conducted by the research team of Heffernan et al investigated the biological effects of AOD9604, a synthetic peptide fragment of HGH, in various mouse models, including lean and obese mice, as well as wild-type (WT) and 3-adrenergic receptor knockout (3-KO) mice

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Gene expression studies revealed that GHK-Cu modulates over 4,000 human genes, with 50% moving toward patterns seen in younger, healthier individuals

Additionally, the peptide's proposed anti-inflammatory properties (via modulation of TNF- and IL-6 in adipose tissue) and potential stimulation of chondrocyte metabolism offered biological plausibility for OA treatment