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Indeed metformin inhibits the mitochondrial oxidative phosphorylation complex I, leading to increased cellular AMP levels and subsequent stimulation of AMPK, an enzyme that plays key roles in the regulation of cellular energy homeostatis

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Methodology We performed a MEDLINE/Google scholar/PubMed search using the terms 'drug-induced liver injury,' 'DILI,' and 'hepatotoxicity, Recent findings in DILI, management of DILI' and analyzed recent literature to identify relevant articles

15 and Extended Data Figs