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Of these: 81% had previously had a heart attack 19% had previously had a nonhemorrhagic stroke (stroke not caused by a blood vessel in the brain breaking or leaking) 13% had peripheral vascular disease The study participants were randomly assigned to receive either Repatha or a placebo (a treatment with no active drug)

This process can start showing visible color within several days of consistent use

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Level B : controlled trials / RCT publications with relevant predefined outcomes (few directly relevant vaginal endpoints identified in accessible primary sources during this review)