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Evidence still evolving The authors assessed the quality of the evidence using the GRADE framework

All nicotine products are concerning, and the health effects and consequences are negatively impactful at every age

The Appeal of Cigarette Alternatives: Affordability without Compromise: As the cost of traditional cigarettes continues to rise, smokers are exploring alternatives that offer both affordability and quality

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This fatigue primarily arises from nicotine's stimulation of adrenaline release, resulting in increased heart rate and elevated blood pressure, which depletes energy reserves and consequently induces feelings of tiredness and drowsiness shortly after use