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Methadone, itself an opioid and a psychoactive substance, is a common treatment for heroin addiction, as is another opioid, buprenorphine

Nicotine may raise heart rate, blood pressure, blood sugar, and stress hormones, which can slightly alter results for glucose, cholesterol, and hormone-related tests

The idea that they could be stems from the fact that e-cigarettes and other vaping devices can supply nicotine without tobacco or other additives and byproducts, like smoke, that are in a traditional cigarette

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